Generation of T cell receptor–retrogenic mice: improved retroviral-mediated stem cell gene transfer
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چکیده
منابع مشابه
Helper virus induced T cell lymphoma in nonhuman primates after retroviral mediated gene transfer
Moloney Murine Leukemia Virus (MoMuLV) causes T cell neoplasms in rodents but is not known to be a pathogen in primates. The core protein and enzyme genes of the MoMuLV genome together with an amphotropic envelope gene are utilized to engineer the cell lines that generate retroviral vectors for use in current human gene therapy applications. We developed a producer clone that generates a very h...
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ژورنال
عنوان ژورنال: Nature Protocols
سال: 2013
ISSN: 1754-2189,1750-2799
DOI: 10.1038/nprot.2013.111